Original Vetus Eyelash Extension Tweezers (5A-SA)

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A review looked at how well 5-ASAs keep symptoms under control in people with Crohn’s who had received medicines to get their symptoms under control (in remission). This review combined data from studies that compared 5-ASAs with a dummy treatment (placebo). It found that 5-ASAs were no more effective than placebo for maintaining remission achieved by medical treatment. Surgically-induced remission Casellas F, Barreiro de Acosta M, Iglesias M, et al. Mucosal healing restores normal health and quality of life in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2012;24:762–9. Remember that medicines often have two names – a scientific name and a brand name. If you are not sure about which medicine you have, ask someone from your IBD team to explain. Some 5-ASAs also come in different forms (formulations). Each one targets a different part of your gut. a b "Asacol HD- mesalamine tablet, delayed release". DailyMed. 15 April 2018 . Retrieved 30 December 2019. Fukuda T, Naganuma M, Takabayashi K et al. Mucosal concentrations of N-acetyl-5-aminosalicylic acid is related to endoscopic activity in ulcerative colitis patients with mesalamine. J Gastroenterol Hepatol. 2020.

Sutherland LR, Robinson M, Onstad G, et al. A double-blind, placebo controlled, multicentre study of the efficacy and safety of 5-aminosalicylic acid tablets in the treatment of ulcerative colitis. Can J Gastroenterol. 1990;4:463–7.Naganuma M, Mizuno S, Nanki K, et al. Recent trends and future directions for the medical treatment of ulcerative colitis. Clin J Gastroenterol. 2016;9:329–36. Nielsen OH, Bondesen S. Kinetics of 5-aminosalicylic acid after jejunal instillation in man. Br J Clin Pharmacol. 1983;16:738–40.

Ulcerative colitis (UC) is a condition that causes inflammation of your large intestine (colon). Some of the symptoms associated with UC include diarrhea, abdominal pain, rectal pain, rectal bleeding, weight loss, fatigue and fever. Ford AC, Kane SV, Khan KJ, et al. Efficacy of 5-aminosalicylates in ulcerative colitis: systematic review and meta-analysis. Am J Gastroenterol. 2011;106:601–16 (617–629). All 5-ASAs are excreted into breastmilk but are considered safe for use. Infants should be monitored for any intolerance to this small amount, with vomiting, diarrhoea or allergic reactions rarely reported with some 5-ASAs. What are the possible side effects of a 5-ASA?Pica R, Cassieri C, Cocco A, et al. A randomized trial comparing 4.8 vs. 2.4 g/day of oral mesalazine for maintenance of remission in ulcerative colitis. Dig Liver Dis. 2015;47:933–7.

Sninsky CA, Cort DH, Shanahan F, et al. Oral mesalamine (Asacol) for mildly to moderately active ulcerative colitis. A multicenter study. Ann Intern Med. 1991;115:350–5. Ito H, Iida M, Matsumoto T, et al. Direct comparison of two different mesalamine formulations for the maintenance of remission in patients with ulcerative colitis: a double-blind, randomized study. Inflamm Bowel Dis. 2010;16:1575–82. After 1 year, more people had their Colitis in remission after taking a rectal 5-ASA compared with people who had been taking placebo. About 62% (62 in every 100 people) who took a rectal 5-ASA had their Colitis in remission compared with 30% (30 in every 100 people) who took placebo. Many brands of 5-ASAs have a special coating around the tablet that allows the medication to be released in the correct part of the bowel. It is important to not crush or chew the tablet as this will damage the coating. Depending on brand the tablet may be best taken with food or on an empty stomach. Granules

StatPearls [Internet].

Feagan BG, MacDonald JK. Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2012;10:CD00054. Bello C, Belaiche J, Louis E, et al. Evolution and predictive factors of relapse in ulcerative colitis patients treated with mesalazine after a first course of corticosteroids. J Crohns Colitis. 2011;5:196–202. Medications other than those listed above may interact with this medication.Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Your doctor will decide which dose you need. It usually depends on which brand of 5-ASA you are taking, as well as how active your condition is. The dose may increase or decrease depending on how you respond. Your IBD team may also change your dose if your condition changes over time. Singh S, Proudfoot JA, Dulai PS, et al. No benefit of concomitant 5-aminosalicylates in patients with ulcerative colitis escalated to biologic therapy: pooled analysis of individual participant data from clinical trials. Am J Gastroenterol. 2018;113:1197–205.