The sutures were removed fourteen days after the surgery from the recipient site that was augmented by the FGG. At the end of 2 months, the ulcers were examined blindly and assessed as “Completely Healed,” “Partially Healed,” “Without Improvement,” or “Worsening. Thus, in the present study, care was taken to obtain a uniform thickness of the graft to be ranged from 1 to 1. The PUSH tool [28] was developed by NPUAP as a quick, reliable tool to monitor the change in pressure ulcer status.

MEBO was smeared successively onto the wounds at a thickness of 1 mm twice daily with a sterile gloved finger. CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited.

It was approved by the ethics review boards of the First Hospital of Harbin and Hongqi Hospital of Mudanjiang Medical College, respectively.

The results of the present study are in accordance with a previous study that used MEBO in treatment of upper gastrointestinal injuries which concluded that MEBO stimulates healing by improving microcirculation, promoting granulation tissue growth, and providing physiologic environment for wound repair by inhibiting bacterial overgrowth and providing a protective membrane preventing bacterial invasion [ 30]. Various clinical trials have been done to test the efficacy of HA gel application in periodontal surgery [ 12, 14, 15]. Participants were included if they met the following criteria: aged 18 to 75 years; pressure ulcers were at stage III or IV according to the european pressure ulcer advisory panel/national pressure ulcer advisory panel (NPUAP) guidelines [ 12]; and at least 1 pressure ulcer.evaluated postoperative pain using VAS for seven days only when comparing the effects of HA and MEBO to negative control on wound-healing in vestibular deepening procedures.

To ensure safe and effective use, emc and the pharmaceutical companies who provide information to this site, encourage reporting of suspected side effects to medicines, vaccines and medical device incidents to the MHRA Yellow Card scheme.In addition, it can also either induce debridement and epithelial repair, or can save costs of treatment for patients and their families. The tracing was subsequently placed on a metric grid and wound area was determined by counting the number of squares in the grid covered by the traced area [ 20]. Results for median and range values for intergroup comparison of color match measured by Visual Analogue Scale score between the three studied groups at all time points are presented in Table 4.

Hyaluronic acid (HA) was also the product of choice in the present study to cover the palatal wound, since it has unique physiochemical and biological properties, being anti-inflammatory, antiedematous, antioxidant, bacteriostatic, and capable of accelerating wound-healing, preventing scar formation, and enhancing tissue regeneration through its ability to retain a large amount of water. as follows: Two horizontal incisions were performed, where the coronal incision was 2 mm apical to the gingival margin of the adjacent teeth and two vertical incisions were traced to delineate the area to be grafted.

The possible mechanisms of MEBO for treating wounds are that it provides a moist environment for the wound healing of pressure ulcers [ 33] and exhibits analgesic and antimicrobial effects. In the three groups, preparation of the recipient site was performed according to Zucchelli and Mounssif [ 17] as follows: Two horizontal incisions were performed, being traced 1 mm coronal to the cementoenamel junction (CEJ) and extending 3 mm mesiodistally. Postoperative pain was measured in this study both directly via VAS and indirectly via consumption of analgesics; thus patients received Ibuprofen 600 mg on surgery day for pain control and were instructed to take Ibuprofen 600 mg only if needed to make sure that any reported pain scores are related to the intervention used [ 3]. However, very limited trials are available to test the efficacy of MEBO in periodontal surgery and intraoral wound-healing [ 16]. Results for mean and SD values for intergroup comparison of wound size (mm) measured by UNC 15 probe and transparent paper (mm) on days 0, 3, 7, 14, and 21 between the three studied groups are presented in Table 3.