Xeomin 50 units powder for solution for injection - Summary of Product Characteristics (SmPC)". (emc). 28 July 2022. Archived from the original on 18 December 2022 . Retrieved 18 December 2022. Multiple uses: One of the most beneficial advantages of BOTOX is that it can be used to treat such a large number of cosmetic and medical conditions, meaning that it is a versatile and invaluable treatment. Disadvantages of BOTOX a b Dressler D, Saberi FA, Barbosa ER (March 2005). "Botulinum toxin: mechanisms of action". Arquivos de Neuro-Psiquiatria. 63 (1): 180–185. doi: 10.1159/000083259. PMID 15830090. S2CID 16307223.

Alam M, et al. (2015). Multicenter prospectivecohort study of the incidence of adverse events associated with cosmetic dermatologicprocedures: Lasers, energy devices, and injectable neurotoxins and fillers. DOI:Hugel's 'Letybo' First in Korea to Obtain Marketing Approval from Australia". Hugel (Press release). 24 November 2022. Archived from the original on 18 December 2022 . Retrieved 18 December 2022– via PR Newswire. Pacik PT (December 2009). "Botox treatment for vaginismus". Plastic and Reconstructive Surgery. 124 (6): 455e–456e. doi: 10.1097/PRS.0b013e3181bf7f11. PMID 19952618.

Košenina S, Masuyer G, Zhang S, Dong M, Stenmark P (June 2019). "Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin". FEBS Letters. 593 (12): 1403–1410. doi: 10.1002/1873-3468.13446. PMID 31111466. Botulinum toxin A is sold under the brand names Jeuveau, Botox, and Xeomin. Botulinum toxin B is sold under the brand name Myobloc. [14] Wittich CM, Burkle CM, Lanier WL (October 2012). "Ten common questions (and their answers) about off-label drug use". Mayo Clinic Proceedings. 87 (10): 982–990. doi: 10.1016/j.mayocp.2012.04.017. PMC 3538391. PMID 22877654.

How does Botox work?

In the case of treatment of infantile esotropia in people younger than 12 years of age, several studies have yielded differing results. [56] [139] Cosmetic [ edit ] As a cosmetic treatment, Botox is relatively new, having only been available since 1990 (although used medically for many years before this) so a lot of people are, understandably, nervous about going for this treatment at a high street clinic. We chat to two Botox doctors about what’s involved and whether it really is worth the fuss to turn that frown upside down. What is a Botox injection? Setlow P (April 2007). "I will survive: DNA protection in bacterial spores". Trends in Microbiology. 15 (4): 172–180. doi: 10.1016/j.tim.2007.02.004. PMID 17336071. Watkins T (15 October 2010). "FDA approves Botox as migraine preventative". CNN. Archived from the original on 27 July 2020 . Retrieved 16 October 2010.

Overview of all the structural information available in the PDB for UniProt: A0A0X1KH89 (Bontoxilysin A) at the PDBe-KB. FDA Approves Botox to Treat Chronic Migraines". WebMD. Archived from the original on 5 May 2017 . Retrieved 12 May 2017. Witmanowski H, Błochowiak K (December 2020). "The whole truth about botulinum toxin - a review". Postepy Dermatologii I Alergologii. 37 (6): 853–861. doi: 10.5114/ada.2019.82795. PMC 7874868. PMID 33603602. While most side effects of Botox are temporary and resolve on their own, there are some potential long-term risks to consider. Frequent Botox injections over an extended period may cause permanent changes to facial expressions or the inability to make certain facial movements. To minimize these risks, ensure you receive Botox injections from a licensed healthcare provider or clinic with proper training. Managing Botox Side Effects

How you prepare

Distant spread of toxin effects - The effects of onabotulinumtoxinA and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults, particularly in those patients who have an underlying condition that would predispose them to these symptoms. Serious side effects of Botox a b Erbguth FJ, Naumann M (November 1999). "Historical aspects of botulinum toxin: Justinus Kerner (1786-1862) and the "sausage poison" ". Neurology. 53 (8): 1850–1853. doi: 10.1212/wnl.53.8.1850. PMID 10563638. S2CID 46559225. The seven toxin serotypes (A–G) are traditionally separated by their antigenicity. They have different tertiary structures and sequence differences. [86] [87] While the different toxin types all target members of the SNARE family, different toxin types target different SNARE family members. [82] The A, B, and E serotypes cause human botulism, with the activities of types A and B enduring longest in vivo (from several weeks to months). [86] Existing toxin types can recombine to create "hybrid" (mosaic, chimeric) types. Examples include BoNT/CD, BoNT/DC, and BoNT/FA, with the first letter indicating the light chain type and the latter indicating the heavy chain type. [88] BoNT/FA received considerable attention under the name "BoNT/H", as it was mistakenly thought it could not be neutralized by any existing antitoxin. [24]