Clinical and Experimental Allergy: "Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy." It possesses a 'very marked sweet taste, being much sweeter than cane-sugar'. The taste is perfectly pure. The minutest quantity of the substance, a bit of its powder scarcely visible, if placed upon the tip of the tongue, causes a sensation of pleasant sweetness throughout the entire cavity of the mouth. As stated above, the substance is soluble to only a slight extent in cold water, but if a few drops of the cold aqueous solution be placed in an ordinary goblet full of water, the latter then tastes like the sweetest syrup. Its presence can hence easily be detected in the dilutest solutions by the taste."

Price, J. M., et al. (1970). Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin [Abstract]. Few studies have analyzed the effects of saccharin alone on blood sugar levels, but several studies have looked at the effects of other artificial sweeteners. Blends of saccharin and aspartame are also often used in diet carbonated soft drinks to ensure that some sweetness remains in the event that syrup is stored beyond aspartame’s relatively short shelf-life. Helpful to people with diabetes This is because it’s not metabolized by your body and does not affect blood sugar levels like refined sugar does.With scientific consensus on safety issues no longer tenable, regulations would be increasingly made in public, often by the public—those consumers who considered themselves just as capable of interpreting the evidence as the so-called experts. For saccharin this regulation by the public reached its apogee in the 1970s, but the pattern had established itself as early as 1908. That contradiction has played a major role in the history of artificial sweeteners. All three “first-generation” sweeteners—cyclamate, saccharin, and aspartame—have been linked to negative health effects. Cyclamate, introduced in 1951, was banned in the United States in 1970. The cyclamate ban reinvigorated the debate over saccharin’s safety, leading to the Saccharin Study and Labeling Act. And aspartame, introduced in 1981, was linked to a supposed increase in brain tumors. In general, everyone should be eating less sugar but lower or no calorie sweeteners can be a useful alternative for people who want to reduce their sugar intake, while maintaining a sweet taste.

Replacing sugar with a low-calorie sweetener may benefit weight loss and protect against obesity ( 9). Whysner J, Williams GM (1996). "Saccharin mechanistic data and risk assessment: urine composition, enhanced cell proliferation, and tumor promotion". Pharmacology & Therapeutics. 71 (1–2): 225–52. doi: 10.1016/0163-7258(96)00069-1. PMID 8910956. The delisting of saccharin led to legislation repealing the warning label requirement for products containing saccharin. [38] In 2001, the U.S. Food and Drug Administration and the state of California reversed their positions on saccharin, declaring it safe for consumption. [29] The FDA's decision followed a 2000 determination by the U.S. Department of Health and Human Services' National Toxicology Program to remove saccharin from its list of carcinogens. It can be confusing to group together sweeteners as the terminologies are open to interpretation. For instance, some products from the stevia plant are marketed as ‘natural’, even though they’re processed and refined. Yet, some of the other products marketed as artificial sweeteners may be derived from naturally occurring substances. For example, sucralose, which is used in Splenda, is derived from sugar (sucrose). Whatever the name, grouping or terminology, it’s important to ask what is in the particular sweetener and whether the sweetener or product has carbohydrate or calories, and how that fits into your individual goals for healthy eating. Sweeteners and safetyEnforcement of the new law fell to the Department of Agriculture’s Bureau of Chemistry and its head chemist, Harvey Washington Wiley. He had long crusaded to rein in what he saw as an out-of-control food industry. In 1908 Wiley proposed the first saccharin ban, taking his case straight to President Theodore Roosevelt. However, most of these studies have been conducted on mice, and those that have been conducted on humans have involved very small sample sizes. Saccharin can be used similarly to table sugar to sprinkle onto food, such as cereal or fruit, or used as a sugar substitute in coffee or when baking. Summary If want to lose weight, or you’re trying to keep your blood glucose levels stable, you may want to know whether artificial sweeteners could help. If you browse around your local supermarket, you’ll see a huge range of sweeteners on offer, so it can be baffling to know which, if any, to go for. So in this section we'll take you through: