The Canadian author arose seemingly from out of nowhere in 2006 when his debut novel De Niro’s Game was rescued from the obscurity of the slush pile at House of Anansi Press. The novel was immediately deluged with plaudits and awards, culminating in his recent win of the IMPAC Dublin Literary Award, the largest English literary prize on the planet. Kramer BH, Nehring V, Buttstedt A, Heinze J, Korb J, Libbrecht R, Meusemann K, Paxton RJ, Séguret A, Schaub F, Bernadou A (2021) Oxidative stress and senescence in social insects: a significant but inconsistent link? Philos Trans R Soc B 376:20190732 She recalls the names of the deceased in a notebook she is writing on while visiting Gitagata and Gitwe, which were reduced to ruins. The book ends with a description of a snake she finds that she uses to symbolise the endurance of what the génocidaires tried to destroy. She lists the names of deceased friends and acquaintances as a form of memorial and burial. Lu K, Zhou J, Deng J, Li Y, Wu C, Bao J (2021) Periplaneta americana oligosaccharides exert anti-inflammatory activity through immunoregulation and modulation of gut microbiota in acute colitis mice model. Molecules 26:1718

This loneliness is coupled with a deep sense of responsibility and shame by the protagonist at his failure to affect an earlier tragedy. The primary narrative arc of this novel is his attempt to atone for this tragedy. And as such, the novel is ultimately a novel of redemption. If reading isn’t so much your thing, there’s a movie to get a sense of what happened.: Hotel Rwanda (2004) where a hotel manager houses over a thousand Tutsi refugees during their struggle against the Hutu militia in Rwanda.Lucas, Julian (February 22, 2018). "Fatal beauty". The New York Review of Books. 65 (3): 27–29. - Cited: p. 27 Sasaki T, Fujiwara H. Detection and distribution patterns of telomerase activity in insects. Eur J Biochem. 2000; 267:3025–3031. doi: 10.1046/j.1432-1033.2000.01323.x. [ PubMed] [ CrossRef] [ Google Scholar] For instance, one of these mechanisms is the accumulation of cells that have undergone cellular senescence in body tissues (Collado et al. 2007) which refers to a permanent but stable arrest in the cell cycle due to the action of stressors which result in the limitation of cellular replication or cell proliferation (Ben-Porath and Weinberg 2005; Herranz and Gil 2018). Therefore, cellular senescence refers to the decline or deterioration of organisms as they age which may also be due to the build-up of physiological or oxidative damage causing what are commonly known as age-associated diseases (de Verges and Nehring 2016; Herranz and Gil 2018; Hseih and Hsu 2011; Lucas and Keller 2014). Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI (2011) Human nutrition, the gut microbiome and the immune system. Nature 474:327–336

Lu K, Zhou J, Deng J, Li Y, Wu C, Bao J. Periplaneta americana oligosaccharides exert anti-inflammatory activity through immunoregulation and modulation of gut microbiota in acute colitis mice model. Molecules. 2021; 26:1718. doi: 10.3390/molecules26061718. [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]

Or maybe in this country, an obscure variety of genocide—consider the combined toll of gun violence, opioids, obesity ( linked to thirteen types of cancer), cardiovascular disease caused by diet/lifestyle, suicide—would continue to distribute itself among the population, disproportionately affecting the poor, no matter who's in power. The infectious contempt through which the anti-hero protagonist views everything around him -- dispensed equally among the struggling immigrant community and the fine-dining bourgeoisie who live in a state of permanent denial -- allows the novel to conspicuously flirt with themes of violence, class consciousness, existential dread, cultural conflict, and the persistent declarations and regrets of human agency. Azuma K, Ifuku S, Osaki T, Okamoto Y, Minami S (2014) Preparation and biomedical applications of chitin and chitosan nanofibers. J Biomed Nanotechnol 10(10):891–2920 [ PubMed] West-Pavlov, Russell (2014). " 'Regardez la vie reprendre': futurity in Véronique Tadjo's L'Ombre d'Imana / The Shadow of Imana.(Report)" (PDF). Tydskrif vir Letterkunde. 51 (2): 114–130. doi: 10.4314/tvl.v51i2.9. - Cited: p. 119 (PDF p. 6/16).