Akkermansia Muciniphila Probiotic Granules * Live Long * Weight Control Dogadan Bizim (5)

£14.995
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Akkermansia Muciniphila Probiotic Granules * Live Long * Weight Control Dogadan Bizim (5)

Akkermansia Muciniphila Probiotic Granules * Live Long * Weight Control Dogadan Bizim (5)

RRP: £29.99
Price: £14.995
£14.995 FREE Shipping

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Borton, M. A. et al. Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome. Microbiome 5, 47 (2017). The new supplement aims to help people with weight management, as well as prevent cardiovascular disease and type II diabetes.

Ansaldo, E. et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Sci. (N. Y.) 364, 1179–1184 (2019). O’Toole, P.W.; Marchesi, J.R.; Hill, C. Next-generation probiotics: The spectrum from probiotics to live biotherapeutics. Nat. Microbiol. 2017, 2, 17057. [ Google Scholar] [ CrossRef] Rantala, A. O. et al. Gamma-glutamyl transpeptidase and the metabolic syndrome. J. Intern. Med. 248, 230–238 (2000). Ringel, Y. et al. High throughput sequencing reveals distinct microbial populations within the mucosal and luminal niches in healthy individuals. Gut microbes 6, 173–181 (2015). As a result, A. muciniphila has been shown to be more effective when it is dead vs. live. It is not alone in this effect; several lactic acid-producing probiotic organisms, such as Lactobacillus and Bifidobacter species, have also been effective when heat-killed. The effectiveness of these "zombie" or dead microbes is challenging the commercial dogma that the only effective probiotic bacteria live as expressed in colony-forming units (CFUs). That is not the case for A. muciniphila . What Makes Akkermansia muciniphila Important?Kim, B.-S. et al. Comparison of the Gut Microbiota of Centenarians in Longevity Villages of South Korea with Those of Other Age Groups. J. Microbiol. Biotechnol. 29, 429–440 (2019). Popular diets like the ketogenic and paleo diets are often deficient in foods promoting this vital organism. It may be necessary for these individuals to supplement their diet with prebiotics, flavonoid-rich extracts, fish oils , and concentrated forms of plant foods like spirulina , barley grass juice, and other green products. Varesi, A.; Campagnoli, L.I.M.; Fahmideh, F.; Pierella, E.; Romeo, M.; Ricevuti, G.; Nicoletta, M.; Chirumbolo, S.; Pascale, A. The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment. Int. J. Mol. Sci. 2022, 23, 12289. [ Google Scholar] [ CrossRef] Han, S. et al. Adequate Lymph Node Assessments and Investigation of Gut Microorganisms and Microbial Metabolites in Colorectal Cancer. OncoTargets Ther. 13, 1893–1906 (2020).

Everard, A. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl. Acad. Sci. USA 110, 9066–9071 (2013). Jian H, Liu Y, Wang X, et al. Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut-Liver-Brain Axes? Int J Mol Sci. 2023 Feb 15;24(4):3900. Kong, C. et al. Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome. Signal Transduct. Target. Ther. 6, 154 (2021). Zheng, J. et al. Dietary inflammatory potential in relation to the gut microbiome: results from a cross-sectional study. Br. J. Nutr. 124, 931–942 (2020). Wu, H. et al. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nat. Med. 23, 850–858 (2017).

Conflicts of Interest

These authors jointly supervised this work: Marie de Barsy, Audrey Loumaye, Michel P. Hermans, Jean-Paul Thissen, Willem M. de Vos. Ottman, N. et al. Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function. PloS one 12, e0173004 (2017).



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