Moreira, A.J.; Ordoñez, R.; Cerski, C.T.; Picada, J.N.; García-Palomo, A.; Marroni, N.P.; Mauriz, J.L.; González-Gallego, J. Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. PLoS ONE 2015, 10, e0144517. [ Google Scholar] [ CrossRef] [ PubMed] Ehrlich, P.J.; Lanyon, L.E. Mechanical strain and bone cell function: A review. Osteoporos. Int. 2002, 13, 688–700. [ Google Scholar] [ CrossRef] Yun, S.-M.; Woo, S.H.; Oh, S.T.; Hong, S.-E.; Choe, T.-B.; Ye, S.-K.; Kim, E.-K.; Seong, M.K.; Kim, H.-A.; Noh, W.C.; et al. Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells. Mol. Cell Endocrinol. 2016, 422, 64–73. [ Google Scholar] [ CrossRef]

It's a bit emotional – I've been covering reception for the last few weeks," says Pierre, "and people tell you how they'll miss it, people ask will they do something with the place? I'm not sure to be honest. We prepare for the worst but hope for the best. Cynically speaking lots of places will be closing in the next few months, but we don't know. Members are happy to come in, they just say you know, we hope you find somewhere else – I say I don't know, but let's make the best of it in the meantime." The song evokes a range of emotions, including longing, desire, introspection, and a yearning for connection. Its simplicity and honesty resonate deeply with listeners. 6. Has “Honey Bones” received any awards or accolades?

HOW LONG DO I COOK CHICKEN THIGHS IN THE OVEN AND WHAT TEMPERATURE?

Some types of honey can also contain infectious microbes that can affect young children and those with a weak immune system.

Bone healing effects of honey was examined by Hajizadeh et al. using a mandibular bone defect healing model in rats [ 87]. A 2 × 2 mm defect was created with an extraoral incision at the mandibular angle. In the experimental group, the defect was filled with sterile honey, under the brand of Medihoney (Derma Sciences Inc., Princeton, USA). The defect was left unfilled in the control group. After two weeks, five samples of the experimental group were in the mineralization phase, while all samples of the control group were in the vascularization phase. After four weeks, the defects were filled in four samples of the experimental group, while all samples of the control group were in the mineralization stage. The histomorphometric assessment revealed that new bone formation in the experimental group was significantly better than the control group after two and four weeks. This study demonstrated that honey could increase and accelerate bone repair of small mandibular defects in rats [ 87]. Cheung, A.M.; Heisey, R.; Srighanthan, J. Breast cancer and osteoporosis. Curr. Opin. Endocrinol. Diabetes Obes. 2013, 20, 532–538. [ Google Scholar] [ CrossRef] [ PubMed] Hussein, S.Z.; Mohd Yusoff, K.; Makpol, S.; Mohd Yusof, Y.A. Gelam Honey Inhibits the Production of Proinflammatory, Mediators NO, PGE(2), TNF-α, and IL-6 in Carrageenan-Induced Acute Paw Edema in Rats. Evid. Based Complement. Altern. Med. 2012, 2012, 109636. [ Google Scholar] [ CrossRef][ Green Version] Zakaria, Z.; Hamid, W.Z.W.A.; Mohamed, M. Tualang honey supplementation improves inflammatory and bone markers among postmenopausal breast cancer patients : A randomised controlled trial. Sains Malays. 2021, 50, 1971–1985. [ Google Scholar] [ CrossRef]Chin, K.-Y.; Wong, S.K.; Ekeuku, S.O.; Pang, K.-L. Relationship Between Metabolic Syndrome and Bone Health—An Evaluation of Epidemiological Studies and Mechanisms Involved. Diabetes Metab. Syndr. Obes. 2020, 13, 3667–3690. [ Google Scholar] [ CrossRef] [ PubMed] Ozgocmen, S.; Kaya, H.; Fadillioglu, E.; Aydogan, R.; Yilmaz, Z. Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Mol. Cell. Biochem. 2007, 295, 45–52. [ Google Scholar] [ CrossRef]

Bone remodelling is a complex and tightly regulated process. Disruption of bone remodelling skewing towards resorption will cause osteoporosis and increase the risk of fragility fracture. Honey is a natural product containing various bioactive ingredients with health benefits, especially polyphenols. Therefore, honey may be a novel dietary supplement to prevent osteoporosis. This review aims to summarize the current evidence on the effects of honey on bone health. The evidence reported so far indicates a skeletal-beneficial effect of honey in animal models of osteoporosis. However, the number of studies on humans is limited. Honey can protect the bone via its antioxidant and anti-inflammatory properties, primarily through its polyphenol content that acts upon several signalling pathways, leading to bone anabolic and antiresorptive effects. In conclusion, honey is a potential functional food for bone health, but the dose and the bioactive contents of honey need to be verified prior to its application in humans. 1. Introduction Miguel, M.; Antunes, M.; Faleiro, M. Honey as a Complementary Medicine. Integr. Med. Insights 2017, 12, 1178633717702869. [ Google Scholar] [ CrossRef][ Green Version] Valko, M.; Leibfritz, D.; Moncol, J.; Cronin, M.T.D.; Mazur, M.; Telser, J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 2007, 39, 44–84. [ Google Scholar] [ CrossRef] [ PubMed] So this could be the reason why alternative medicine recommends combining these 2 ingredients. In this way, they could both decrease inflammation and protect the joints against free radicals. Souza, P.P.C.; Lerner, U.H. The role of cytokines in inflammatory bone loss. Immunol. Investig. 2013, 42, 555–622. [ Google Scholar] [ CrossRef]

Ahmed, S.; Sulaiman, S.A.; Othman, N.H. Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model. Evid. Based Complement. Altern. Med. 2017, 2017, 5904361. [ Google Scholar] [ CrossRef][ Green Version]

Pulpit Commentary Verse 24. - Pleasant words are as an honeycomb. "Pleasant words" are words of comforting, soothing tendency, as in ch. 15:26; Psalm 19:10. The writer continues his praise of apt speech. The comparison with honey is common in all languages and at all times. Thus Homer sings of Nestor ('Iliad,' 1:248, etc.) - Rennert, G.; Pinchev, M.; Gronich, N.; Saliba, W.; Flugelman, A.; Lavi, I.; Goldberg, H.; Fried, G.; Steiner, M.; Bitterman, A.; et al. Oral Bisphosphonates and Improved Survival of Breast Cancer. Clin. Cancer Res. 2017, 23, 1684–1689. [ Google Scholar] [ CrossRef] Tencerova, M.; Kassem, M. The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis. Front. Endocrinol 2016, 7, 127. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version]

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Syam, Y.; Prihantono, P.; Majid, S.; Sjattar, E.L.; Kana, M.; Usman, A.N. The effect of apis Dorsata honey as a complementary therapy to interleukin-6 (IL-6) levels and T lymphocytes of post-chemotherapy breast cancer patients. Breast Dis. 2021, 40, S97–S101. [ Google Scholar] [ CrossRef] Abu-Serie, M.M.; Habashy, N.H. The ameliorating effect of the combined extract from Greek Thymus vulgaris and bee’s honey on the hydrocortisone-induced osteoporosis in rat bone cells via modulating the bone turnover, oxidative stress, and inflammation. RSC Adv. 2018, 8, 28341–28355. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] Age-related chronic inflammation also plays an essential role in the pathogenesis of osteoporosis by influencing bone remodelling [ 14]. In the presence of RANKL, the cytokines TNF- α, interleukins (IL)-6, and IL-1 will cause an excessive formation of osteoclasts while inhibiting osteoblast activities [ 15]. Proinflammatory cytokines like TNF- α also stimulates osteoclast development and increases the production of macrophage colony-stimulating factors (M-CSF) by bone marrow stromal cells (BMSCs) [ 16, 17]. They also suppress osteoblasts from releasing the RANKL decoy receptor, osteoprotegerin (OPG). This decoy primarily prevents the binding of RANKL with its corresponding receptor to stimulate osteoclastogenesis [ 15]. Ahmed, S.; Sulaiman, S.A.; Baig, A.A.; Ibrahim, M.; Liaqat, S.; Fatima, S.; Jabeen, S.; Shamim, N.; Othman, N.H. Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action. Oxidative Med. Cell. Longev. 2018, 2018, e8367846. [ Google Scholar] [ CrossRef][ Green Version]