Savlon Scar Prevention Gel 50g, First Aid Treatment to Help Soothe Minor Wounds and Burns and Reduce Likelihood of Scarring (Pack of 1, Packaging May Vary)

Product Information

Results from the project suggest that the gel could be used to improve healing treatments and techniques for other complex wound types. Coconut oil contains the substance monolaurin, a fatty acid with antimicrobial properties. Fatty acids found in vegetable oils are assumed to play a large part in helping wounds heal. A person can use coconut oil on a wound to help reduce the risk of contracting an infection.

Aloe vera is a plant belonging to the cactus family. It contains a substance that is rich in both vitamins and minerals. In contrast, the unique NUS invention takes a comprehensive ‘all-in-one’ approach to wound healing, accelerating the process on several fronts. Results from lad tests of the gel showed that, when coupled with magnetic stimulation, it healed diabetic wounds approximately 240 per cent faster by increasing the cells’ growth rate and more than doubles the amount of collagen produced, which is vital in the healing process.

RESULTS:

Anti-inflammatory hydrogels enhance the recruitment of macrophages to the wound bed and reduce ROS levels. These functions contribute to wound healing by allowing for the transition from the inflammatory to the proliferation stage, increasing the rate of healing, and minimizing the length of the healing period. Some hydrogels show intrinsic anti-inflammatory properties. For instance, CS and its derivatives can regulate the inflammation process by enhancing the secretion of TGF-β, PDGF, and IL-1, which helps accelerate angiogenesis, fibroblast proliferation, and collagen synthesis [ 92, 99]. HA, which is a major component of the skin ECM, also shows inherent anti-inflammatory properties [ 100, 101]. HA is involved in the signaling cascades that trigger the recruitment of inflammatory cells around the wound, enhance cytokine expression, and decrease inflammation to protect the tissue damage [ 102, 103]. Anti-inflammatory properties can also be added to hydrogels by chemically attaching anti-inflammatory agents, such as phenolic compounds [ 78, 93, 94, 96, 98]. Those compounds can be obtained from plant extracts, honey, or antimicrobial peptides. Anti-inflammatory compounds are mostly recognized by the immune modulatory pathways to regulate inflammation and reduce ROS levels around the wound. Stimulating the body’s innate immune system by modifying the hydrogels with targeting agents can also be used to improve anti-inflammatory properties. For example, targeting the sphingosine-1-phosphate receptor could be an approach to activate inflammatory cells [ 104], which helps the transition from the inflammatory phase to the proliferative phase of wound healing [ 105, 106, 107, 108, 109, 110]. Hydrogels containing bioceramics can also exhibit anti-inflammatory activity in wound healing applications [ 111]. For instance, the controlled release of silicon (Si) ions from bioceramic particles that were encapsulated in gelatin/PCL nanofibers reduced inflammation while increasing angiogenesis, collagen deposition, and re-epithelization [ 112, 113, 114]. Brine shrimp lethality bioassay method was used to evaluate the in vitro cytotoxic effect of the formulated AM, AV and AM+AV gels (Fig. ​ (Fig.2a6). 2a6). A concentration of 0.25mg/ml did not affect the viability. At a concentration of 0.5mg/ml and 0.75mg/ml, the mortality rate of the nauplii was 1%. Increasing the concentration (2mg/ml) of gels led to an increase in mortality rate to 3–4% (Fig. ​ (Fig.2 2a6). Slower degradation of the dextran hydrogel with the high content of nondegradable PEGDA and higher cross-linking density Wound healing is a natural physiological reaction to tissue injury. However, wound healing is not a simple phenomenon but involves a complex interplay between numerous cell types, cytokines, mediators, and the vascular system. The cascade of initial vasoconstriction of blood vessels and platelet aggregation is designed to stop bleeding. This is followed by an influx of a variety of inflammatory cells, starting with the neutrophil. These inflammatory cells, in turn, release a variety of mediators and cytokines to promote angiogenesis, thrombosis, and reepithelialization. The fibroblasts, in turn, lay down extracellular components which will serve as scaffolding. [1] A person can often treat minor wounds at home. However, in some instances, wounds need medical attention.

A person can mix turmeric with warm water to make a paste. They can then apply the paste to the wound and cover it with a clean bandage. According to a 2020 review, several clinical trials have demonstrated the efficacy of garlic in treating wounds. It stated that in preclinical studies, aged garlic extract showed wound healing potential depending on the dosage. An ointment to support and speed up the natural healing of minor superficial wounds like cuts, abrasions and scratches as well as first and smaller second degree burns. The inflammatory phase begins with hemostasis and chemotaxis. Both the white cells and thrombocytes speed up the inflammatory process by releasing more mediators and cytokines. Besides the platelet-derived growth factor, other factors promote collagen degradation, the transformation of fibroblasts, the growth of new vessels, and re-epithelialization. All of the processes occur at the same time but in a synchronized fashion. Mediators like serotonin and histamine are released from platelets and increase cellular permeability. The platelet-derived growth factor attracts fibroblasts and, along with transforming growth factor, enhances the division and multiplication of fibroblasts. The fibroblasts, in turn, synthesize collagen.This is major step forward in active wound care,” explained Professor Tay. “Our goal is to provide an effective and convenient wound-healing solution that improves outcomes for millions around the world.” Elastoplast Wound Healing Ointment is free of colourants, fragrances and animal-derived substances. The ointment can be combined with Elastoplast standard plasters, such as Fabric, Sensitive, and Water Resistant plasters. Beside active ingredients, the applicability of burn wound healing gel is dependent on the properties such as pH, appearance, homogeneity, and viscosity. Carbopol is a widely used gelling agent for producing burn-healing gels for skin application. CMC-Na salt is another agent used alongside with carbopol [ 46]. However, in this study the gel was prepared from human amniotic membrane extract (AM), Aloe vera extracts (AV), and a combination of both AM+AV using 6% CMC-Na salt as a gelling agent. Extensive studies confirm the effectiveness and safety of lyophilized amnion as a wound dressing and grafting materials for promoting the healing process and preventing infections [ 47]. Khorasani et al. , (2009) reported that AV cream or gel could be more effective than silver sulfadiazine cream in treating burn wound healing [ 30]. The end products (gels) in all three conditions evaluated in this study were homogenous, granule less and of a whitish creamy color (Fig. ​ (Fig.1a10, 1a10, 1b3, 1c). In addition, pH of all formulations ranged between 6.5–6.9, and this pH does not interfere with skin physiology [ 48]. Erythema and edema are the common symptoms of skin irritation which lasts for three to 7 days [ 49]. Our formulated gels did not induce any irritation including no erythema or edema on rat skin upon topical application for a period of 7days (Fig. ​ (Fig.4c). 4c). Thus, CMC-Na salt, AM and AV extract formulated gel could be useful as wound healing gel as the gels have good spreadability and consistency. In vitro and in vivo studies clearly and collectively demonstrated the potentials of the formulated gels from amnion when combined with Aloe vera. In this preliminary research, we found that the formulated gels can induce and accelerate the proliferation and attachment of HaCaT and HFF1 cells (Fig. ​ (Fig.3), 3), and promote wound healing in vitro (Fig. ​ (Fig.4a, 4a, b) [ 50]. Amnion has been reported to facilitate the migration of epithelial cells, reinforces attachment, and promotes proliferation [ 51]. Representative microscopic images for HFF1 and HaCaT cell attachment and proliferation. a HFF1 cells (2h to 8h) and ( b) HaCaT cells (3h to 12h) attachment test. c Proliferation tests of HFF1 for 2, 4, and 6days. d The proliferation of HaCaT from day 3 to day 6 in media with and without gels

Macroscopic evaluation of wound closure and quantitative measurement of wound contraction and re-epithelialization Chemical hydrolysis, enzymatic hydrolysis, acidic/ salting out, alkaline extraction and acidic extraction. In vitro biocompatibility and cytotoxicity test were done as described by Khan et al., (2012) [ 39]. To do the heparinized human blood biocompatibility assay, AM, AV and AM+AV gels were diluted with different ratios of blood. A blood sample of the same donor diluted with DW and saline water (SW) at the same ratios as done for the gels was used as a control. After an incubation time of 2h at room temperature, the blood/gel mixtures were spread on glass slides, and observed under a light microscope for possible morphological changes in the blood cells. Elastoplast Wound Healing Ointment can be used at any stage of the healing process on superficial open wounds and damaged skin. Wound healing, especially in the field of diabetic foot ulcers, has always been a challenging arena. Diabetic foot patients do not heal as well as normal patients and their healing journey is often prolonged,” said Assistant Professor Francis Wong Keng Lin, Consultant,Department of Orthopaedic Surgery, Sengkang General Hospital.Inflammatory cells, such as neutrophils, monocytes, and endothelial cells, adhere to a fibrin scaffold formed by platelet activation. The neutrophils enable phagocytosis of cellular debris and bacteria, allowing for decontamination of the wound. [4] Col makes up the major component of the extracellular matrix (ECM) in humans [ 4] while gelatin is a Col derivative [ 12]. Col is a perfectly organized structure as a three-dimensional (3D) scaffold that surrounds the cells. Thus, it has a dominant influence in maintaining the structural and biological integrity of the ECM. Being a natural component of the human body, it has been categorized as one of the major biomaterials widely used in wound healing [ 4]. Nonetheless, the physicochemical properties of Col and gelatin greatly influence the mechanism of skin wound healing. One 2016 review suggests that turmeric can be effective in helping wounds heal faster. It showed that the curcumin present in the spice stimulated the production of the growth factors involved in the healing process. It also showed that curcumin accelerated the management of wound restoration.