Gingivitis (gum disease): A double-blind parallel three-arm (0.12% chlorhexidine, 0.025% HA, and a water-based antioxidant mouthwash containing beta-carotene and vitamin E and C as active ingredients) clinical trial was conducted in 75 people 18 to 23 years with biofilm-induced gingivitis. It showed that all three interventions significantly reduced the plaque index (PI) after seven days compared to the baseline data. However, chlorhexidine showed a larger PI reduction than the HA and antioxidant mouthwashes. Hafsa J, Chaouch MA, Charfeddine B, et al. Effect of ultrasonic degradation of hyaluronic acid extracted from rooster comb on antioxidant and antiglycation activities. Pharmaceutical Biology. 2016;55(1):156-163. doi:10.1080/13880209.2016.1232740 Yang YJ, Lee WY, Kim YJ, Hong YP. A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome. Int J Environ Res Public Health. 2021;18(5):2383. doi:10.3390/ijerph18052383 Chronic pain: A randomized, double-blind, placebo-controlled clinical study of 72 people taking 45 milliliters (3 tablespoons) of high molecular weight HA by mouth during the first two weeks of the study resulted in reduced pain and pain medication usage. Of note, during the last two weeks of the study, the dose was reduced to 30 milliliters (2 tablespoons), and no further decrease in chronic pain was observed.

Majeed M, Majeed S, Narayanan NK, Nagabhushanam K. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytotherapy research: PTR. 2019;33(5):1457-1468. doi:10.1002/ptr.6338

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Cicek N, Yildiz N, Alpay H. Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder. Journal of Pediatric Urology. 2020;16(3):366.e1-366.e5. doi:10.1016/j.jpurol.2020.02.009 Urinary tract infections: A study conducted in 10 children aged 2 to 18 years with spina bifida and neurogenic bladder who performed clean intermittent catheterization (a technique for bladder drainage) showed that the instillation of 40 milligrams (mg) HA into the bladder weekly for four weeks then monthly for the following three months reduced symptomatic recurrent urinary tract infections. However, further multicenter randomized, controlled clinical trials with larger sample sizes and longer follow-ups are needed to confirm such promising results. Di Cicco M, Peroni D, Sepich M, Tozzi MG, Comberiati P, Cutrera R. Hyaluronic acid for the treatment of airway diseases in children: little evidence for few indications. Pediatric Pulmonology. 2020;55(8):2156-2169. doi:10.1002/ppul.24901 Jensen GS, Attridge VL, Lenninger MR, Benson KF. Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study. Journal of Medicinal Food. 2015;18(1):95-101. doi:10.1089/jmf.2013.0174

Wang SJ, Wang YH, Huang LC. The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain. Medicine. 2021;100(5):e24252. doi:10.1097/md.0000000000024252‌ Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutrition Journal. 2015;15(1). doi:10.1186/s12937-016-0130-8 Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Clinical, Cosmetic and Investigational Dermatology. 2017;10:267-273. doi:10.2147/CCID.S141845 Yang JJ, Zhang XM. Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and Its influence on joint function and bone metabolic markers. Computational and Mathematical Methods in Medicine. 2022;2022:1-6. doi:10.1155/2022/6078254Jang KM, Park YG, Choi WK, et al. Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study. Current Medical Research and Opinion. 2021;37(9):1573-1580. doi:10.1080/03007995.2021.1950132 Colletti A, Cicero AFG. Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence. International Journal of Molecular Sciences. 2021;22(23):12920. doi:10.3390/ijms222312920 Osteoarthritis: In a randomized study comparing the effect of intra-articular (within the joint) HA injection to betamethasone injection, people with osteoarthritis of the thumb underwent one cycle of three injections (one per week) of 0.5 cubic centimeters (cm 3) of HA 5 milligrams (mg). Intra-articular HA injection requires a prescription and is given as a shot to your knee joint by a trained healthcare professional. Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. Wounds. 2016;28(3):78-88.‌ Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutrition Journal. 2014;13(1). doi:10.1186/1475-2891-13-70

Hyaluronic Acid is a potent hydrator and natural moisturiser. Don’t let the word “acid” scare you: we produce it naturally in our own bodies too! Enhanced by a range of natural ingredients, Q+A Hyaluronic Acid Facial Serum will quench even the thirstiest skin. Mikosinski J, Di Landro A, Kasztalska-Kazmierczak K, et al. Efficacy and safety of a hyaluronic acid-containing cream in the treatment of chronic, venous, or mixed-origin leg ulcers: a prospective, multicenter randomized controlled trial. Wounds. 2021;33(11):285-289.Simental-Mendía M, Sánchez-García A, Vilchez-Cavazos F, Acosta-Olivo CA, Peña-Martínez VM, Simental-Mendía LE. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials. Rheumatology International. 2018;38(8):1413-1428. doi:10.1007/s00296-018-4077-2 Lephart ED, Naftolin F. Menopause and the skin: old favorites and new innovations in cosmeceuticals for estrogen-deficient skin. Dermatology and Therapy. 2020;11(1):53-69. doi:10.1007/s13555-020-00468-7 Q+A Hyaluronic Acid Daily Moisturiser refreshes your complexion with the best hydrating ingredients! Whilst the word 'acid' might seem scary, we produce Hyaluronic Acid naturally in our own bodies, as it helps to keep our skin hydrated! Unfer V, Tilotta M, Kaya C, et al. Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight. Expert Opinion on Drug Metabolism & Toxicology. 2021;17(7):823-840. doi:10.1080/17425255.2021.1931682

Maheu E, Rannou F, Reginster JY. Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys. Seminars in Arthritis and Rheumatism. 2016;45(4):S28-S33. doi:10.1016/j.semarthrit.2015.11.008Monfort J, Rotés-Sala D, Segalés N, et al. Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study. Joint Bone Spine. 2015;82(2):116-121. doi:10.1016/j.jbspin.2014.08.008 How to recycle: Remove the lid from the tube. Wash out the tube and dry. Both our lids and tubes are 100% recyclable so can be disposed of in your domestic recycling. Hyaluronic Acid Crosspolymer helps draw moisture into the skin and holds it safely in the upper layers of the skin to keep you looking fresh and hydrated. Polyglutamic Acid pairs perfectly with Hyaluronic Acid and helps draw even more moisture into the skin by forming a protective barrier that reduces moisture loss throughout the day - they are the ultimate pairing for dry and dehydrated skin. In addition, a unique Rice Bran extract delivers plenty of antioxidants and soothing Vitamin E for protection against environmental stressors and keeping your complexion feeling super soft.