You will be presented with lots of information about your PSP, the screenshot below is from my PSP 1000: After showing a change of –0.11 in ONLS score at 15 months, patients in the high-dose PXT3003 group had an additional mean improvement of –0.17 in the following 45 months. The low-dose group didn’t see as much efficacy signal, but still had improvements of –0.17 in ONLS score in the final 45 months of treatment, following a –0.05 change seen at the 15-month mark. Notably, among patients receiving placebo in the original 15-week period who then switched to low-dose or high-dose PXT3003 during period 1 and high dose during period 2, the mean change in ONLS score was –0.11 in the final 45 months compared with a worsening change of 0.17 in the original 15-week treatment period. If you are installing ME just run the installer and follow the directions on the display. Once complete you should now have permanent CFW. Note: On the 15/01/2015 Sony released PSP firmware 6.61, some three and a half years after the last 6.60 update. It's of no benefit to you updating to 6.61 after all this time, however the custom firmware has now been updated to support 6.61. So you can now follow this guide if you happen to have updated to 6.61. You will be able to play any game released to date on either 6.60 or 6.61, you will also be able to connect to the PSN and buy stuff. The best of both worlds I think you will agree

There are 2 options for permanent CFW for the 2000 model. You can use cIPL flasher or use Infinity 2.0. CIPL flasher was meant for only 1000 and some 2000 models. Please read carefully below on how to determine if cIPL Flasher or Infinity 2.0 should be used. The system connects to the network using an access point. If you do not have a connection saved, select [New Connection] to create a connection. Dark_Alex for the initial M33 CFW who guided us mentally through several CFW generations by giving good examples on how to patch Sony OFW. In PLEO-CMT, a revised statistical analysis plan was developed to consider the high amount of missing data because of the discontinuation of patients in this treatment arm. At the trial’s end, both high- and low-dose PXT3003 groups demonstrated decreased scores on the ONLS, indicating disability improvement, whereas those receiving placebo had worsening disability progression. The change in ONLS score was greatest in the high-dose group, for which the mean effect was –0.37 points ( P = .008). Between the low-dose and placebo groups, the mean effect was not statistically significant ( P = .287). bbtgp, Dark_AleX, Noobz, Team C+D, M33 Team, and coyotebean for their new psardumper source to get the OFW binaryRemember you can only permanently install this firmware on a PSP 1000 or a PSP 2000 that is not an 88 v3 version. If you are installing PRO, launch PRO Update first. Follow the directions on the display and then launch cIPL Flasher to make it permanent.

Unzip and copy the program to your PSP > Game folder like you did with the custom firmware installer, then load PSP Ident up on your PSP: Attarian S, Young P, Brannagan TH, et al. A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot-Marie-Tooth type 1A. Orphanet J Rare Dis. 2021;16(1):433. doi:10.1186/s13023-021-02040-8 Something to note is that you can only permanently install this firmware on a PSP 1000 or a PSP 2000 that is not an 88 v3 version. However its very easy to re load the custom firmware on a 88V3 PSP 2000, PSP 3000, PSP Go or E1000. I will cover finding out your PSP version later in this guide, all you need to know for now is that if you own a PSP you can follow this guide and get homebrew applications running on your PSP. If the firmware is permanently installed it means your PSP will boot directly in to the custom firmware when powered on, if not it means you will have to enable it again by launching a simple app. This however only needs doing from a cold boot, if you leave the PSP in standby like most people do (you probably do this without realising) then you will not need to enable it. CMT1A, the most common form of CMT, is caused by a duplication of the PMP22 gene that is responsible for the production of the peripheral myelin sheath protein. Its duplication leads to abnormal levels of PMP22 protein, which then leads to a failure in the production of normal myelin. In data from preclinical studies, PXT3003 was shown to suppress PMP22 production and improve neuromuscular function.

The PSP 2000 is able to have permanent custom firmware installed via cIPL flasher if it’s an early revision model. Sony patched this with newer motherboard versions. cIPL (custom IPL) installs to the nand and allows the PSP to load the custom firmware files on boot. This is the preferred method for this model over installing Infinity. Infinity itself isn’t custom firmware but an exploit that allows PRO or LME to be enabled permanently. You are free to use whatever method you prefer but this guide suggests cIPL if your PSP 2000 is able to install it. As for ME and PRO, you can choose whatever one you want. Both are very similar in what features they offer and you can uninstall and try the other one if you are curious. For the sake of this guide, I personally use ME and find that the plugin manager a helpful feature which isn’t included in PRO. bbtgp and Draan for their PrxEncrypter source code to produce the signed fake vshmain module for permanent patch

Mathieulh, Geohotz, TPU and everyone else involved for making PSP signing possible, making the Minna No Sukkiri Exploit redundant. The PSP 1000 is able to have permanent custom firmware installed via cIPL flasher. cIPL (custom IPL) installs to the nand and allows the PSP to load the custom firmware files on boot. This is the preferred method for this model over installing Infinity. Infinity itself isn’t custom firmware but an exploit that allows PRO or LME to be enabled permanently. You are free to use whatever method you prefer but this guide suggests cIPL. As for ME and PRO, you can choose whatever one you want. Both are very similar in what features they offer and you can uninstall and try the other one if you are curious. For the sake of this guide, I personally use ME and find that the plugin manager a helpful feature which isn’t included in PRO. Pharnext announces on-schedule completion of patient enrollment in its pivotal phase III trial of PXT3003, the PREMIER trial, for the treatment of Charcot-Marie-Tooth disease type 1a. News release. Pharnext SA. May 30, 2022. Accessed July 11, 2022. https://pharnext.com/en/press-releases/pharnext-announces-on-schedule-completion-of-patient-enrollment-in-its-pivotal-phase-iii-trial-of-pxt3003-the-premier-trial-for-the-treatment-of-charcot-marie-tooth-disease-type-1aWe can see that my PSP is a 1.2 the 1 been a PSP 1000 and it has a 79 V3 motherboard, which is capable of having custom firmware permanently flashed to it. PXT3003 (PHARNEXT SA), a novel fixed-dose synergistic combination of baclofen, naltrexone, and sorbitol, is being evaluated in the pivotal phase 3 PREMIER study (NCT04762758) of patients with Charcot- Marie-Tooth disease type 1a (CMT1A), a neurological disease for which there are no curative or symptomatic medications approved. The international, randomized, double-blind, 2-arm, placebo-controlled trial is taking place in 52 centers across the United States, Canada, Europe, and Israel, with topline data expected to be announced in Q4 2023. 1 Now your PSP can run unsigned code we will find out if you can permanently flash the custom firmware to your PSP. If you press the button with a connection selected, the options menu will be displayed. From the menu, you can edit connection settings or delete the connection. Connect Following the data announcement, Shahram Attarian, MD, PhD, head of the Neuromuscular Diseases Service and ALS Department at Timone Hospital in Marseilles, France, said in a statement that “as an investigator involved since the beginning in the clinical development of PXT3003 in CMT1A, I find these long-term safety and efficacy data very encouraging. Being able to stabilize, or even improve, patients with CMT1A is an extremely worthwhile goal, particularly as these individuals will inevitably decline following the long-term natural course of the disease with the currently available standard of care.” 3 Attarian, who served as lead investigator for PLEO-CMT and PLEO-CMT-FU, currently serves as lead investigator of the PREMIER trial. REFERENCES

Below will go over setting up the ability to swap out the digital comics or SensMe channels section on your PSP menu to the Fast Recovery or LME Launcher. That way it isn’t cluttering up your game list. This part isn’t required but it is a great feature to have if you don’t plan on mkaing the CFW permanent.The dose of PXT3003 tested in PREMIER corresponds to the high dose tested in the pivotal phase 3 trial, PLEO-CMT (NCT02579759). That study randomly assigned 323 individuals with mild to moderate CMT1A to either 5 mL of high- or low-dose PXT3003 or placebo, twice daily for up to 15 months, with change in ONLS score at 12 and 15 months as the primary end point. The high-dose treatment arm was prematurely stopped in September 2017 because of an unexpected formulation issue, after which the FDA and European Medicines Agency requested an additional phase 3 study to confirm the efficacy and safety of PXT3003, leading to PREMIER. 2