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COVID-19 has caused significant interference to our business and the COVID-19 intelligence from GlobalData has helped us reach better decisions around strategy. These two highlights have helped enormously to understand the projections into the future concerning our business units, we also utilise the project database to source new projects for Liebherr-Werk to use as an additional source to pitch for new business.” In Kintor Pharma's stage II clinical trials 120 patients were treated with 5mg/day applied topically as a 0.5% solution. The result was a significant increase in hair density with no serious adverse events reported. The latest clinical trial data is something Matt Dominance went over in his latest YouTube video on it and in the first trials it seems they used high dosages up to 48mg and these were detectable in the bloodstream but once they readjusted dosages for Phase 2 they used 5mg as the highest dosage twice daily and at 6 months, they were claiming better gross and similar net results or better than Finasteride and Minoxodil used for even 1 year. So that to me shows a massive potential for people afraid of sides from Finasteride who never did anything at all and lost hair or those who had sides and couldn't save their hair as a result either.
UK, Europe, America Enclomiphene Citrate SERM | Ligand Chem, UK, Europe, America
EQS Newswire. (2022, August 30). Kintor 2022 interim results: Pruxelutamide and KX-826 show positive results, business value has been presented. Bloomberg.com. Retrieved October 1, 2022. Obtain information on LOA and PTSR for competitors’ drugs to plan your clinical development, commercialization and marketing strategiesAdditionally, Kintor’s hair loss drug is also being explored as a treatment for acne vulgaris. The use of pyrilutamide as a treatment for acne vulgaris is still in the preclinical stage in the United States, but it’s already started phase II clinical trials in China. How Does Pyrilutamide Work for Hair Loss?
Pyrilutamide - Wikipedia
The ML model is further supplemented with an additional algorithm proprietary to GlobalData to predict PTSR and LoA. Each of the data attributes are assigned a weighted average score based on its direct impact on a drug’s clinical transition. The weighted average score represents a scale between a minimum to a maximum value based on the Raw Scores. The final score of an attribute is achieved by multiplying the Raw Score with the Weighted Score for each data attribute. All scores are added to determine the PTSR value.So for those of us currently suffering hair loss, the gold standard has been for many years the adapted dosages of "Accidental Hair Loss Treatments" like Finasteride/Dutasteride and Minoxodil in oral or topical forms. Finasteride is the only oral medication that's approved to treat androgenic alopecia. However, it's also used to treat enlarged prostates. The cost of finasteride can vary depending on a number of factors, ranging from your insurance provider to what the drug has been prescribed for. But in general, it's more costly to buy brand-name products than generic versions of this medication.
Pyrilutamide KX826 and Hair Growth | The Hair Loss Show Pyrilutamide KX826 and Hair Growth | The Hair Loss Show
In December 2022, the results of another phase-2 clinical study were published, on the treatment of female pattern hair loss (female AGA). Right now, joining a pyrilutamide clinical trial is highly unlikely as enrollment for men in the United States and women in China are currently closed. You’d only be considered as a participant if you were a man with moderate pattern hair loss symptoms living in China.The study reported that applying 5 milligrams of pyrilutamide twice a day produced the best improvements in hair growth, increasing hair count by 22.73 hairs per cm ² after 24 weeks of treatment. In comparison to the placebo group’s hair count, the twice-a-day 0.5% concentration of pyrilutamide increased hair counts by 15.34 hairs per cm ² . (4-6) There are ongoing clinical trials to prove its efficacy and safety, which may eventually lead to better accessibility and FDA approval. Yeah, i am not naive at all to the type of people in this world, but just as we currently don't let a minority of people dictate things being completely pulled from market with loud voices, i'm sure the science will be followed well enough and this product should hopefully see a success in helping people with hair loss. However, this new treatment of Pyrilutamide seems to ensure that DHT in the body or scalp is not decreased but rather targets and cuts the ability of DHT on the Androgen Receptor. So this hypothetically would eliminate the concerns around Finasteride which causes a multitude of side affects for guys and concerns for many. Pyrilutamide (KX-826) is under development for the treatment of androgen associated alopecia and acne vulgaris.The drug candidate is for external use and administered through topical route. It acts by targeting androgen receptor. It was also under development for the treatment of whelk and diabetic foot ulcer.
Pyrilutamide from Ligand Chem in the UK : r/tressless - Reddit Pyrilutamide from Ligand Chem in the UK : r/tressless - Reddit
a b c CApatent 2829322,Tong Y,"Substituted Thioimidazolidinone Androgen Receptor Antagonists and Uses Thereof",published 2012-03-08,issued 2017-01-10, assigned to Suzhou Kintor Pharmaceuticals, Inc Jianzhong Zhang, chairman of the Department of Dermatology, Peking University People’s Hospital, is the leading principal investigator. The primary endpoint for the trial is the change from baseline versus placebo in TAHC at the end of week 24.Pharma, K. (2022, August 3). KINTOR Pharma announces completion of patient enrollment in phase II clinical trial of KX-826 for treatment of Androgenetic Alopecia in the US. Kintor Pharma Announces Completion of Patient Enrollment in Phase II Clinical Trial of KX-826 for Treatment of Androgenetic Alopecia in the US. Retrieved October 1, 2022 .
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