Expanded and integrated treatment of local signaling circuits, including AKAPs and signaling complexes that include protein kinase A, adenylyl cyclase, and phosphodiesterase, and localized puffs and waves of Ca2+ In-text Worked Examples take students through particular difficult equations to improve their quantitative problem-solving skills.

Achieve is a comprehensive set of interconnected teaching and assessment tools that incorporate the most effective elements from Macmillan Learning's market leading solutions in a single, easy-to-use platform. A design guided by learning science research. Co-designed through extensive collaboration and testing by both students and faculty including two levels of Institutional Review Board approval for every study of AchieveData Analysis Problems (one at the end of each chapter), contributed by Brian White of the University of Massachusetts–Boston, encourage students to synthesize what they have learned and apply their knowledge to the interpretation of data from the literature. Course and book-specific resources including adaptive quizzing (Learning Curve) to personalize the experience for students

Authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles of biochemistry. Question Bank with thousands of additional questions to create an assignment from scratch or add to a curated assignment Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors Box 5–1 Medicine: Carbon Monoxide: A Stealthy Killer New medical box on the use of topoisomerase inhibitors in the treatment of bacterial infections and cancer, includes material on ciprofloxacin (the antibiotic effective for anthrax) New descriptions of volatile lipids used as signals by plants, and pigments of bird feathers derived from colored lipids in plant foodsThe definitive Lehninger Principles of Biochemistry, Eighth Edition, continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new coauthor Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. The summary of principals and the highlighting of these principals throughout the text. This is really helpful! The Boxes with additional information, particularly clinical relevance of the material. Most of my students are pre-med and it helps them engage in the material better if there is clinical relevance. The problems at the end of the chapter. These are really beneficial for the students who want to make sure they understand the material." --Robin Haynes, Harvard University The Glyoxylate Cycle Box 16–1 Moonlighting Enzymes: Proteins with More Than One Job Box 16–2 Synthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing!